Universität zu Köln

Zegke, M. (Corresponding author)* ; Grödler, D. ; Roca Jungfer, M. ; Haseloer, A. ; Kreuter, M. ; Neudörfl, J. M. ; Sittel, T. ; James, C. M. ; Rothe, J. ; Altmaier, M. ; Klein, A. ; Breugst, M. ; Abram, U. ; Strub, E.* ; Wickleder, M. S.

Angewandte Chemie / International edition 2022 Vol. 61 Issue 3 

DOI: 10.1002/anie.202113777

Ammonium pertechnetate reacts in mixtures of trifluoromethanesulfonic anhydride and trifluoromethanesulfonic acid under final formation of ammonium pentakis(trifluoromethanesulfonato)oxidotechnetate(V), (NH₄)₂[TcO(OTf)₅]. The reaction proceeds only at exact concentrations and under the exclusion of air and moisture via pertechnetyl trifluoromethanesulfonate, [TcO₃(OTf)], and intermediate Tc^VI species. ⁹⁹Tc nuclear magnetic resonance (NMR) has been used to study the Tc^VII compound and electron paramagnetic resonance (EPR), ⁹⁹Tc NMR and X-ray absorption near-edge structure (XANES) experiments indicate the presence of the reduced technetium species. In moist air, (NH₄)₂[TcO(OTf)₅] slowly hydrolyses under formation of the tetrameric oxidotechnetate(V) (NH₄)₄[{TcO(TcO₄)₄}₄] ⋅10 H₂O. Single-crystal X-ray crystallography was used to determine the solid-state structures. Additionally, UV/Vis absorption and IR spectra as well as quantum chemical calculations confirm the identity of the species.

Vázquez, S. M. ; Endepols, H. ; Fischer, T. ; Tawadros, S.-G. ; Hohberg, M. ; Zimmermanns, B. ; Dietlein, F. ; Neumaier, B. ; Drzezga, A. ; Dietlein, M. ; Schomäcker, K. (Corresponding author)

Molecular imaging & biology 2022 Vol. 24 Pages 115-125

DOI: 10.1007/s11307-021-01632-x

Uddin, M. S.; Qaim, S. M. (Corresponding author) ; Scholten, B.; Basunia, M. S.; Bernstein, L. A.; Spahn, I.; Neumaier, B.

Molecules 2022 Vol. 27 Issue 3 Pages 768

DOI: 10.3390/molecules27030768

The β+-emitting radionuclide 86gY (t1/2 = 14.7 h) forms a matched-pair with the β−-emitting therapeutic radionuclide 90Y (t1/2 = 2.7 d) for theranostic application in medicine. This approach demands a precise knowledge of the positron emission probability of the PET nuclide which was until recently rather uncertain for 86gY. In this work, an 86gY source of high radionuclidic purity was prepared and a direct measurement of the positron emission intensity per 100 decay of the parent (hereafter “positron emission intensity”) was performed using high-resolution HPGe detector γ-ray spectroscopy. The electron capture intensity was also determined as an additional check by measuring the Kα and Kβ X-rays of energies 14.1 and 15.8 keV, respectively, using a low energy HPGe detector. From those measurements, normalized values of 27.2 ± 2.0% for β+-emission and 72.8 ± 2.0% for EC were obtained. These results are in excellent agreement with values recently reported in the literature based on a detailed decay scheme study.

Régio Brambilla, C. (Corresponding author); Veselinović, T. ; Rajkumar, R. ; Mauler, J. ; Matusch, A. ; Ruch, A. ; Orth, L. ; Ramkiran, S. ; Sbaihat, H. ; Kaulen, N. ; Khudeish, N. Y. ; Wyss, C. ; Heekeren, K. ; Kawohl, W. ; Rota Kops, E. ; Tellmann, L. ; Scheins, J. ; Boers, F. ; Neumaier, B. ; Ermert, J. ; Lang, M. ; Stüsgen, S. ; Herzog, H. ; Langen, K.-J. ; Shah, N. J. ; Lerche, C. W. ; Neuner, I

Translational Psychiatry 2022 Vol. 12 Issue 1 Pages 6

DOI: 10.1038/s41398-021-01763-3

Kaulen, N.* ; Rajkumar, R.* ; Régio Brambilla, C.* ; Mauler, J.* ; Ramkiran, S.* ; Orth, L. ; Sbaihat, H.* ; Lang, M.* ; Wyss, C. ; Rota Kops, E.* ; Scheins, J.* ; Neumaier, B.* ; Ermert, J.* ; Herzog, H.* ; Langen, K.-J.* ; Lerche, C.* ; Shah, N. J.* ; Veselinović, T. ; Neuner, I. (Corresponding author)*

Human brain mapping

DOI: 10.1002/hbm.25778